Arthritis is a disease of epidemic proportions, but it has been
around for so many centuries that it is considered by most people
as a part of growing old or a consequence of physical injury.
Arthritis is in fact a far more complex disease than is generally
known. For instance, Dorland's Medical Dictionary describes 27
different types of arthritis, and that does not include such
diverse conditions as systemic lupus erythematosus, scleroderma,
fibromyalgia, and numerous other conditions which some authorities
consider to be types of arthritis. One authority states that
there are approximately 100 causes for arthritis
Arthritis is thought to affect more than 50
million Americans, and is generally accepted to be the leading
cause of movement limitation and disability. It deserves and
receives a great deal of research and medical attention. There
are hundreds of drugs, procedures, and medical aids and devices
directed at coping with the many manifestations of the disease.
Given this degree of complexity, certainly no one agent alone
could ever be expected to manage or cure "arthritis"
in its entirety. New agents take their place in the spectrum
and make a contribution. Now there is a relatively new discovery
of a natural substance, cetyl myristoleate, which shows promise
of making a great contribution in non-infective types of arthritis.
Cetyl myristoleate was discovered and isolated by one person,
working alone, on a quest to find a cure for arthritis. Harry
W. Diehl, while employed by the National Institute of Arthritis,
Metabolism, and Digestive Diseases, specialized in sugar chemistry.
He used his chemical knowledge and research instincts to great
advantage, identifying and characterizing over 500 compounds,
several of which were patented by the National Institutes of
Health (NIH). His most significant discovery before cetyl myristoleate
was a method of synthesizing 2-deoxydextroribose, a sugar used
in the preparation of oral polio vaccine by Dr. Jonas Salk.
Diehl's interest in discovering a way to help
victims of arthritis began over 40 years ago when his friend
and next door neighbor, a carpenter, developed severe rheumatoid
arthritis. His condition deteriorated over time until he became
disabled. The neighbor had a family to support, but his arthritis
made that impossible. Diehl is a deeply religious man whose feelings
overwhelmed him as his friend's condition worsened. Harry thought,
"Here I am working at the National Institutes of Health,
and I have never seen anything that was good for curing arthritis."
He decided to establish a laboratory in his home and embark on
a search for something to relieve the pain and disability of
his neighbor and the millions of people who suffer from arthritis.
Unfortunately, he was too late to help the neighbor, but Diehl's
research did lead to the discovery of cetyl myristoleate, which
may someday be hailed as one of the significant nutritional discoveries
of the 20th century.
As a researcher, Diehl knew that finding a cure for arthritis
first meant inducing the disease experimentally in research animals.
He started with mice, and quickly realized that he was unable
to induce arthritis in them. Diehl said he tried every way he
could to give those mice arthritis, but they just would not get
it. Then, he contacted a researcher in California who wrote to
him, "If you or anyone else can give mice arthritis, I want
to know about it, because mice are 100% immune to arthritis."
At that moment, Diehl's research instincts told him that what
he wanted was already somewhere in those mice.
It was a long, tedious job, working on his
own in his spare time, but Diehl finally found the factor - cetyl
myristoleate - that protected mice from arthritis. As Diehl said,
"It didn't come on a silver platter to me, but after years
of chemical sleuthing and just old-fashioned chemical cooking,
I found it!" On thin layer chromatography of methylene chloride
extract from macerated mice, Diehl noticed a mysterious compound,
which was subsequently identified as cetyl myristoleate. As Diehl
was to prove, cetyl myristoleate circulates in the blood of mice
and makes them immune to arthritis.
Cetyl myristoleate is now known to exist in
sperm whale oil and in a small gland in the male beaver. At this
time no other sources in nature are known to contain cetyl myristoleate.
While the first amounts of cetyl myristoleate for experimentation
were extracted from mice, Diehl quickly developed a method for
making cetyl myristoleate in the lab by the esterification of
myristoleic acid.Next Page
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Cetyl Myristoleate News.
Case of 4
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