Nutrients may be why some smokers avoid cancer

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Nutrients may be why some smokers avoid cancer

LONDON (Reuters) - Smokers who have higher levels of vitamin B6 and certain essential proteins in their blood have a lower risk of getting lung cancer than those deficient in these nutrients, according to study by cancer specialists.

Health

Scientists at the International Agency for Research on Cancer (IARC) said that although they had not found a causal link, the results may be a clue to why some smokers never get lung cancer and some non-smokers or former smokers do.

Lung cancer is the most common form of the disease in the world and 90 percent of all cases are caused by cigarette smoking. It kills 1.2 million people a year.

About 10 to 15 percent of smokers develop lung cancer -- although they often die of other smoking-related causes like heart disease, stroke or emphysema. Lung cancer is also known to kill people who never smoked or who gave up years ago.

The IARC study, which looked at around 900 people with lung cancer, found a link to low levels of vitamin B6 and an amino acid called methionine, found in protein like meat, fish and nuts. B6 is also found in meat, nuts, vegetables and bananas.

"What we have found is that these two things are strong markers of lung cancer risk, but we have not shown they are causing that rise in risk," said Paul Brennan of the Lyon-based IARC, who led the study and published its findings in the Journal of the American Medical Association (JAMA) on Tuesday.

"This indicates that diet may have an important role in lung cancer development, but it's still a little premature to say simply that if you change your diet and eat more foods with these vitamins then you'll change your future lung cancer risk."

NUTRIENTS KEY TO DNA HEALTH

Brennan's team studied around 900 lung cancer patients, mostly smokers but also including about 100 who never smoked and 260 who had quit.

Brennan said the change in risk of lung cancer linked to B6 and methionine levels was the same for all three groups, although of course the overall risk of getting the disease was much higher in the smokers to start with.

"For the two nutrients together, the risk reduction was about 60 percent," he said. "Obviously if you had a very high risk because you smoke, then a 60 percent reduction of that is quite important, although not as important as quitting smoking."

Brennan said his findings appeared to reinforce previous research which suggested deficiencies in B vitamins may increase the probability of DNA damage and subsequent gene mutations.

A Swedish study in 2005 found that women with high levels of vitamin B6 had a lower risk of developing colorectal cancer.

"Basically, these B vitamins and nutrients are all involved in the pathway which is responsible for the creation and maintenance of DNA," Brennan said. "So obviously you would want that pathway to work as well as possible."

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Supplemental Facts-Serving - Size: 1 fl. oz (2 Tablespoons)
Amount per Serving % Daily Value Amount per Serving % Daily Value
Calories 40 Iron (as gluconate) 4 mg 22%
   Calories from Fat 0 g Magnesium (as citrate) 300 mg 75%
Total Fat 0 g Zinc (as gluconate) 15 mg 100%
   Saturated Fat 0 g Selenium (as methionine) 100 mcg 143%
   Cholesterol 0 g Copper (as gluconate) 1 mg 50%
Total Carbohydrates 9 g Manganese (as gluconate) 5 mg 250%
    Dietary Fiber 0 g Chromium (as polynicolinate) 200 mcg 167%
    Sugars 9 g Potassium (as citrate) 100 mg 3%
Sodium 0 g Choline (as bitartrate) 30 mg *
Protein 0 g Inositol 30 mg *
Vitamin A (as palmitate beta carotene) 10,000 IU 200% Boron (as amino acid complex) 1 mg *
Vitamin C (as ascorbid acid) 1,000 mg 1667% Amino Acid Mix 125 mg *(Proprietary Formula- alanine, arginine, aspartic acid,cystine, glutamic acid, glycine, histidine, isoleucine,phenylalanine, proline, serine, threonine, tryptophan,tyrosine,valine)
Vitamin D3 (as cholecalciferol) 200 IU 50%
Vitamin E (as d-alpha tocopheryl) 200 IU 667%
Vitamin K(as Menadione)  30 mg 38% Thiamin (as mononitrate)  30 mg 2000%
Riboflavin (as 5-phosphate) 30 mg 1765% Grape Seed (Vitis vinifera) p.e.**4:1 25 mg *
Niacin (as Niacinamide) 30 mg 150% CoEnzyme Q10 5 mg *
Vitamin B6(as pyridoxine hydrochloride) 30 mg 1500% Dimethylglycine 25 mg *
Folic Acid 400 mcg 100% Para-amino benzoic acid 30 mg *
Vitamin B12(as cyanocobalamin) 500 mcg 8333% Bioflavonoids 13 mg *
Biotin 300 mcg 100% Plant Derived Mineral Complex 14,175 ml *
Panothenic Acid(as pantothenol) 150 mg 1000% GDL (glucono delta lactone) 150 mg *
Calcium (as citrate, di calcium phosphate dihydrate) 600 mg 60% *Percent Daily Values based on 2,000 calorie diet.
*Daily Value not established.
**Standardized Plant Extract
Other Ingredients:Purified Water, Vegetable Glycerin, Sodium Erythorbate, Citric Acid, Malic Acid, Span 60, Tween 80, Natural Orange Flavor, Natural Berry Flavor, Potassium Sorbate, Sodium Benzoate
This product is made from all natural ingredients and has no starch, wheat or yeast. Absolutely no animal derivativesare used in the production or testing of Ultimate Classic. Color and taste may vary.

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