SELENIUM IMPORTANCE:SELENIUM LIVER CANCER A major antioxidant nutrient, protects cell membranes and prevents free radical generation


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What is the use and function of SELENIUM?
SELENIUM LIVER CANCER

SELENIUM IMPORTANCE:SELENIUM LIVER CANCER
A major antioxidant nutrient, protects cell membranes and prevents free radical generation thereby decreasing the risk of cancer and disease of the heart and blood vessels.
SELENIUM, HEPATITIS B, AND LIVER CANCER

Selenium (Se) is an essential trace element that functions as a component of enzymes involved in antioxidant protection and thyroid hormone metabolism. In several intra- and extra-cellular glutathioine peroxidases and iodothyronine 5'-deiodinases, selenium is located at the active centers as the selenoamino acid, selenocysteine (SeCYS). At least two other proteins of unknown function also contain SeCYS. Although SeCYS is an important dietary form, it is not directly incorporated into these specific selenium-proteins; instead, a co-translational process yields tRNA-bound SeCYS. In contrast, selenium as seleno-methionine is incorporated non-specifically into many proteins, as it competes with methionine in general protein synthesis. Therefore, tissues often contain both specific, as well as the nonspecific, selenium-containing proteins when both SeCYS and selenomethionine are consumed, as found in many foods.SELENIUM, HEPATITIS B, AND LIVER CANCERSELENIUM LIVER CANCER

Medical surveys show that increased selenium intake decreases the risk of breast, colon, lung and prostate cancer. Selenium also preserves tissue elasticity; slows down the aging and hardening of tissues through oxidation; helps in the treatment and prevention of dandruff.
SELENIUM LIVER CANCER

DEFICIENCY SYMPTOMS:SELENIUM LIVER CANCER
May result in premature aging, heart disease, dandruff, loose skin.
SELENIUM LIVER CANCER
Selenium deprivation reduces activities of the selenium-dependent peroxidases and deiodinases. The signs in animals depend upon vitamin E status and appear only when both nutrients are limiting. They vary according to species. For example, selenium- and vitamin E-deficient animals show myopathies of skeletal (e.g., sheep, cow, horse), cardiac (pig) or smooth (dog, cow) muscle; hepatic necrosis (rat, pig); increased capillary permeability (chicken); or pancreatic acinar degeneration (chicken). Characteristic signs of selenium deficiency have not been described in humans, but very low selenium status is a factor in the etiologies of a juvenile cardiomyopathy (Keshan Disease) and a chondrodystrophy (Kaschin-Beck Disease) that occur in selenium-deficient regions of China.SELENIUM LIVER CANCER
Toxicity:
Selenium toxicity is characterized by dermatologic lesions; selenotic animals and humans develop brittle hair and nails/hooves. Sporadic cases of selenium-poisoning have been reported involving industrial or accidental exposures to selenium-compounds. In certain rural Chinese communities chronic intakes of very high amounts (several milligrams per day) of selenium were linked to skin, hair and nail abnormalities which disappeared upon resuming regular selenium intakes. Selenium has been identified as the cause of birth deformities in migratory wildfowl in a wetland area (Kesteron Reservoir, CA) which receives selenium-enriched irrigation wastewater This case involved the biological amplification of selenium by aquatic plants which were important in the diets of affected animals.
SELENIUM LIVER CANCER
Diet recommendations:SELENIUM LIVER CANCER
The Recommended Dietary Allowances are: 0-0.5 years, 10 µg; 0.5-1.0 years, 15 µg; 1-6 years 20 µg; 7-10 years, 30 µg; males, 11-14 years, 40 µg; females, 11-14 years, 45 µg; males an females 15-18 years, 50 µg; adult males 70 µg; adult females, 55 µg; pregnant females, 65 µg;and lactating females, 75 µg.
SELENIUM LIVER CANCER

U.S. RDA FOR SELENIUM
babies:
birth to 6 months
6 months to 1 year

10 mcg per day
15 mcg per day
children:
1 to 6 years

7 to 10 years

20 mcg per day
30 mcg per day
men and boys:
11 to 14 years
15 to 18 years
19 to 51+ years

40 mcg per day
50 mcg per day
70 mcg per day
women and girls:
11 to 14 years
15 to 18 years
19 to 51+ years

45 mcg per day
50 mcg per day
55 mcg per day
pregnant women 65 mcg per day
nursing mothers 75 mcg per day

Food sources:SELENIUM LIVER CANCER
The most important sources in American diets are meats, fish and grains. Additionally, some foods such as Brazil nuts can have relatively high selenium concentrations. Foods of low protein content, including most fruits and vegetables, do not provide substantial amounts of selenium. Food selenium appears to be absorbed with efficiencies of 60-80%; the greatest factor affecting the utilization of food selenium is its chemical form.SELENIUM LIVER CANCER

Recent research: Anti-tumorigenic effects of high levels of selenium have been demonstrated in several animal models. The mechanism(s) of anti-tumorigenic effects of selenium and the possible role of selenium in affecting the risk of human cancer are not clear.

Selenium weathered from rocks under alkaline and oxidizing conditions form selenates, which are highly toxic. Selenite and selenates are produced by soil microorganisms from less soluble forms of selenium. These forms are highly soluble in alkaline soils, thus facilitating uptake of selenium by certain plants. Rainy regions are less likely to experience the problem from naturally occurring selenium because selenium and other salts have been flushed from the soil profile. Selenium does not occur in sedimentary rocks from the pre-Cretaceous period such as those in the northeastern U.S., or in the coastal regions where the soils are formed by coastal deposits or recent volcanic ash. There are also low-selenium areas in Montana and Idaho were the soil is formed from granites and old metamorphic rock; and areas in Arizona and New Mexico where the soil is formed from tertiary volcanic rock (Ullrey 1981)

Nationwide selenium deficiency in livestock is a far more common occurrence than toxicity. More typically selenium is added to livestock feed as a supplement because the element is lacking in the locally grown forage.

For further information:

Burk, R.F., ed. (1994) Selenium in Biology and Human Health. Springer-Verlag, New York, NY

Combs, G.F., Jr. (1994) Essentiality and toxicity of selenium: a critique of the Recommended Dietary Allowances and the Reference Dose. In: Risk Assessment of Essential Elements (Mertz, C., Abernathy, C. & Olin, S.S., eds.), pp. 167-183. International Life Sciences Institute Press, Washington, DC.



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Ultimate Selenium - 90 Capsules #20971

Selenium is one of the most documented and widely studied trace elements known. Numerous studies have shown the importance of selenium supplements to the body. Lifts moods and reduces anxiety. Designed for high absorption Selenium is a strong antioxidant which is thought to protect us against the ravages of free radicals.
Selenium has been found to prevent some cancers by up to 69%! Reduced cancer deaths by 50% in a university study. Increases immune system. Found to increase some immune factors by up to 79%!


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