High rates of hepatitis B virus infection and primary liver cancer are present in the Qidong county of China. Surveys demonstrated an inverse association between selenium level and cancer incidence, as well as hepatitis B virus infection.SELENIUM, HEPATITIS B, AND LIVER CANCER
A four-year animal study showed that dietary supplement of selenium reduced the hepatitis B infection by 77.2% and liver precancerous lesion by 75.8% of ducks, caused by exposure to natural environmental factors.SELENIUM, HEPATITIS B, AND LIVER CANCER
SELENIUM, HEPATITIS B, AND LIVER CANCER
A study was undertaken among the general population of 130,471. Individuals in five townships were involved for observation of the preventive effect of selenium. The 8-year follow-up data showed reduced liver cancer incidence by 35.1% in table salt fortified with selenium vs the non supplemented population. On the withdrawal of selenium from the treated group, liver cancer rates began to increase. However, the inhibitory response to hepatitis B was sustained during the 3-yr after the treatment was stopped.SELENIUM, HEPATITIS B, AND LIVER CANCER
SELENIUM, HEPATITIS B, AND LIVER CANCER In another study by the authors 226 hepatitis B positive persons provided either 200 micrograms of a selenium tablet or an identical placebo daily for 4 yr showed that 7 of 113 subjects were diagnosed as having liver cancer in the placebo group, whereas no incidence of liver cancer was found in 113 subjects supplemented with selenium. Again on cessation of treatment, liver cancer developed at a rate comparable to that in the control group, demonstrating that a continuous intake of selenium is essential to sustain its effect.SELENIUM, HEPATITIS B, AND LIVER CANCER
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Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Yu SY, Zhu YJ, Li WG Bio Trace Elem Res 1997 Jan;56(1):117-124
SELENIUM, HEPATITIS B, AND LIVER CANCE